Another returning gameplay feature is the Vault-Tec Assisted Targeting System (V.A.T.S.), which can play a critical part in combat. Players can also find game cartridges with retro themed mini-games which can be played on the Pip-Boy.

The player character, the Sole Survivor, accesses the in-game menus through a Pip-Boy to manage statistics, maps, data, and items. Enemies such as mole rats, mirelurks, raiders, super mutants, deathclaws, and ghouls return to the series. Additional features include a split-piece armor system (reminiscent of the armor system in The Elder Scrolls III: Morrowind), base-building, a dynamic dialogue system, an in-depth crafting system that makes use of every lootable object in the game as a source of raw material and more. The gameplay is largely similar to that of Fallout 3 and New Vegas, with the ability to switch from first to third-person view. As a result of the synth-focused narrative, the Sole Survivor, as well as the player, are faced with ethical questions such as how far people should experiment with science, the morality of creating sentient living machines that express emotions and suffering, and what it means to be human. Along the way, the Sole Survivor discovers a world in fear of the Institute, consumed by paranoia of a race of robotic yet also biological human-like beings known as synth. Fallout 4 is set in and around the Boston area in 2287, 10 years after Fallout 3. The story of Fallout 4 focuses on a spouse, the Sole Survivor of Vault 111, as they search for their missing child, Shaun. Fallout 4 expands on ideas shown in a quest in Fallout 3 regarding a mysterious institute, The Railroad and synths. In contrast, the New Vegas references in 4 are more minor. While Fallout 4 could be played as a standalone game, players who skip 3 will miss some impact and context during some scenes. While Fallout 4 was the next installment after Fallout: New Vegas, Fallout 4 is more of a direct narrative sequel to Fallout 3 than New Vegas due to some characters from 3 returning in 4, continuing their storylines. It was released on Microsoft Windows, PlayStation 4, and Xbox One on November 10, 2015, except in Japan, where it was released on December 17, 2015, due to the need to censor some footage and references to atomic war, while still keeping the plot intact. It is the fifth major installment in the Fallout series (eighth overall). Fallout 4 is a post-apocalyptic role-playing game developed by Bethesda Game Studios and published by Bethesda Softworks.

Fallout 4 clothing mods are invisible